MAP Kinase Signaling System

《英文msh词典》MAP Kinase Signaling System
[主题词] MAP Kinase Signaling System
[同义词] MAP Kinase Cascade
[同义词] MAP Kinase Signaling Pathways
[入口词] MAP Kinase Modules
[入口词] MAP Kinase Signaling Cascades
[入口词] Cascade,MAP Kinase
[入口词] Cascades,MAP Kinase
[入口词] Kinase Cascade,MAP
[入口词] Kinase Cascades,MAP
[入口词] Kinase Module,MAP
[入口词] Kinase Modules,MAP
[入口词] MAP Kinase Cascades
[入口词] MAP Kinase Module
[入口词] Module,MAP Kinase
[入口词] Modules,MAP Kinase
[中文释义] MAP激酶信号系统
[英文释义] An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators,which act in response to extracellular stimuli,trigger the cascades by activating the first member of a cascade,MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals,there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway,the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway,and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.